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People receiving Moderna COVID vaccine report more adverse reactions than Pfizer recipients



More people taking Moderna’s coronavirus vaccine reported side effects than those who received the Pfizer shot, according to a recent study.

Researchers analyzed reports from more than 3 million wax recipients collected via v-safe, a Centers for Disease Control and Prevention program that tracks responses to immunizations.

Nearly 70 percent said they had some form of injection site reaction such as pain or swelling, and half reported general side effects such as fatigue or chills, the study found.

“A greater percentage of participants who received the Moderna vaccine compared to the Pfizer-BioNTech vaccine reported reactogenicity; this pattern was more pronounced after the second dose, ”the researchers noted.

Joseph Kuresa receives a COVID-19 vaccine shot from Shaun Murry on April 7, 2021 in Los Angeles.
Joseph Kuresa receives a COVID-19 vaccine shot from Shaun Murry on April 7, 2021 in Los Angeles.
Los Angeles Times via Getty Images

Of those who received the Moderna shot, 73 percent said they had a reaction at the injection site compared to 65 percent of the people who received the Pfizer vaccine, the study found.

Nearly 51 percent of Moderna recipients reported experiencing full-body symptoms compared to 48 percent of those who received the Pfizer shot.

The reports came from more than 3.6 million people who received their first dose of a COVID-19 vaccine by February 21 and completed at least one v-safe health study within seven days of getting jabbed.

The difference widened after the second dose, according to reports from about 1.9 million people who completed these check-ins after receiving shot # 2, the study said.

Thinking Elementary School Education Resource Assistant Raymundo Armagnac, 65, will receive his COVID-19 vaccination from Nursing Practitioner Mary Ann Topico on February 17, 2021.
Thinking Elementary School education resource assistant Raymundo Armagnac, 65, will receive his COVID-19 vaccination from nurse practitioner Mary Ann Topico on February 17, 2021.
Los Angeles Times via Getty Images

Close to 82 percent of the people who received their second Moderna vaccine had injection site pain compared to less than 69 percent of those with Pfizer.

Overall, 74 percent of Moderna recipients said they experienced whole-body symptoms, compared to 64 percent of people who received Pfizer wax.

A nurse fills a syringe with the Moderna COVID-19 vaccine at a vaccination site at a senior center on March 29, 2021 in San Antonio, Texas.
A nurse fills a syringe with the Moderna COVID-19 vaccine at a vaccination site at a senior center on March 29, 2021 in San Antonio, Texas.
Getty Images

About 40 percent of people with Moderna specifically reported getting chills compared to only 22 percent of the Pfizer receiver.

“Data from millions of v-safe participants indicate that injection site pain is common after both the first and second doses of either mRNA-based vaccine,” the researchers noted.

The study was published Monday in the peer-reviewed medical journal JAMA.


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