For most of human history, Parkinson's disease (PD) has been a rare disorder. But industrialization demographics and by-products now contribute to an imminent Parkinson's pandemic, according to experts writing in a supplement to the Journal of Parkinson's Disease . They say that this pandemic can be solved by Parkinson's community, which forms a "PACT" to prevent the disease, advocates policies and resources aimed at slowing down the spread, taking care of all those affected and treating effective and new therapies.
Neurological disorders are now the major cause of disability globally, and the fastest growing neurological disorder in the world is PD, a slow progressive disorder affecting movement, muscle control and balance. In 1855, forty years after Dr. James Parkinson first described the condition, died about 22 people of 15 million in England and Wales by PD. In 2014, about 5,000 to 10,000 people of 65 million died in the UK by PD. From 1990 to 2015, the number of people with PD worldwide doubled to over six million. Driven mainly by aging, this figure is expected to double to over 12 million by 2040, and additional factors, including increasing lifespan, declining smoking rates and increasing industrialization, may increase the burden to over 17 million.
"In 2040, we can really talk about a pandemic that will result in increased human suffering as well as profound societal and medical costs. How can society be alerted to this scenario and implement changes in research priorities and care programs to reduce the burden of Upcoming Pandemic? "warned Patrik Brundin, MD, Ph.D., Van Andel Research Institute, Grand Rapids, MI, USA, editor of Journal of Parkinson's Disease .
According to senior author Ray Dorsey, MD, of the Department of Neurology and the Center for Health and Technology, the University of Rochester Medical Center, Rochester, NY, the United States, "The PD & # 39; s tide rises and spreads. The toll on them with the disease and those around them. The cargo strain has negative health consequences on its own. The economic cost of PD is also significant, ready to grow and at least in the US overwhelmingly aimed at institutional care, which desires. " The incidence of PD increases with age, and the world's population is aging as the number and proportion of people over 65 grow rapidly. The combined result of these two factors is an unprecedented increase in the number of people with PD.
Independent of PD, global life expectancy has increased by six years over the past two decades. This is likely to increase the number of people with advanced PD who are more difficult to treat and may have limited access to care. Numerous studies have shown that the risk of PD falls among smokers by approx. 40%. If the association is causal, which must continue to be determined, decreasing rates of smoking can lead to higher rates on PD.
Finally, the by-products of industrialization can contribute to the increasing rates of PD. Specific pesticides, solvents and heavy metals have been associated with PD exposure to these substances. It is possible to prevent.
"In the last century, society has successfully faced pandemics of polio, breast cancer and HIV to varying degrees. The success of these efforts was unrestrained activism," Dr. Dorsey. Following these examples, the authors suggest that Parkinson's community forms a "PACT" to prevent, fight, care and treat the disease by understanding the root causes (environmental, genetic and biological), expanding new care models seeking to bring expert care to all and the development of new, highly effective therapies. The most effective therapy (levodopa) is now fifty years old.
"We hope this article will raise awareness of the challenge and provide the basis for a community-leading response to solving one of the major health challenges of our time," co-authored and associate editor of the Journal of Parkinson's disease Bastiaan R. Bloem, MD, Ph.D., from Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, Holland.
"The PD pandemic is preventable, not inevitable", the authors conclude.
Parkinson's disease: A threatening pandemic
E. Ray Dorsey et al., The New Evidence of the Parkinson's Pandemic, Journal of Parkinson's Disease (2018). DOI: 10.3233 / JPD-181474
New evidence for an upcoming Parkinson's disease pandemic identified (2019, January 29)
January 29, 2019
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