A new compound that visualizes and kills antibiotic-resistant superbugs has been discovered by researchers at the University of Sheffield and Rutherford Appleton Laboratory (RAL).
The team, led by Professor Jim Thomas, of the University of Sheffield's Department of Chemistry, tests new connections developed by his Ph.D. student Kirsty Smitten on antibiotic-resistant gram-negative bacteria, including pathogenic E. coli .
Gram-negative bacterial strains can cause infections, including pneumonia, urinary tract infections and blood infections. They are difficult to treat because the cell wall of the bacteria prevents medication from entering the microbe.
Antimicrobial resistance is already responsible for 25,000 deaths in the EU each year, and unless this rapidly emerging threat is addressed, it is estimated by 2050 to kill more than 1
Doctors have not had a new treatment for Gram-negative bacteria in the last 50 years, and no potential drugs have passed clinical trials since 2010.
The new drug association has a number of exciting opportunities. As Professor Jim Thomas explains: "Since the connection is luminescent, it shines when exposed to light. This means that the absorption and effect on bacteria can be followed by the advanced microscope techniques available at RAL.
" This breakthrough could lead for vital new treatments for life-threatening superuges and the increasing risk of antimicrobial resistance. "
The studies in Sheffield and RAL have shown that the compound appears to have several modes of action, making it more difficult for resistance to appear in the bacteria. The next step in the study will be to test it against other multi-resistant bacteria.
A recent report on antimicrobial resistant pathogens put the World Health Organization several gram-negative bacteria at the top of the list, stating that new treatments for these bacteria were prioritized 1 critical because they cause high-death infections, quickly become resistant to all current treatments and often become retrieved from the hospital s.
The research, published in the journal ACS Nano describes the novel compound killing gram-negative E. coli including a multi-drug resistant pathogen is said to be responsible for millions of antibiotic-resistant infections worldwide annually.
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Kirsty L. Smitten et al., Using nanoscopy to detect the biological activity of antimicrobial joints showing potential activity against pathogenic, multi-drug resistant, gram-negative bacteria, ACS Nano (2019). DOI: 10.1021 / acsnano.8b08440
New connection killing antibiotic resistant superbugs discovered (2019, May 28)
May 28, 2019
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