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Home https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ Health https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ Inactive Ingredients in Drugs May Be Less Inactive Than You Think

Inactive Ingredients in Drugs May Be Less Inactive Than You Think



The medicines you take in soup of active and inactive ingredients.

Active ingredients are the ones that provide a therapeutic benefit, while inactive ingredients are just that – inactive – they don't react in the body and are instead, to enhance the properties of the medication itself, such as its taste, appearance and ability to be absorbed by the body. [7 Bizarre Drug Side Effects]

But it turns out that active ingredients may not be as well as inactive as we think: A new study finds that, in some patients, inactive ingredients can trigger allergic reactions or other symptoms of food intolerance. ] The study was published today (March 1

3) in the journal Science Translational Medicine. (Of note, three of the study authors hold a patent on a system that examines the inactive ingredients in pills.)

The researchers started looking into inactive ingredients after senior study author Dr. Giovanni Traverso, an assistant professor in MIT's Department of Mechanical Engineering and a gastroenterologist at Brigham and Women's Hospital, treated a patient with celiac disease who had a reaction to a medication that contained active ingredients derived from wheat products.

Traverso and his team The researchers found some studies on patients who had allergic reactions to active ingredients such as lactose – present in about 45 percent of pills – as well as certain kinds of chemical dyes.

But they did not find any studies looking at whether or not certain active ingredients could cause extreme, but probably more common symptoms of food intolerance, such as bloating or stomach aches.

ingredients themselves, using a database run at the National Library of Medicine. They found that active ingredients make up, on average, just over a quarter (29 percent) of the weight of an oral pill; The remaining 71 percent of the weight comes from inactive ingredients. On average, there are more than eight different active ingredients but can contain up to 35, they reported.

But over 35 inactive ingredients are available. In fact, drug companies have around 1,000 active ingredients to choose from when manufacturing pills, the researchers found. Of these ingredients, such as peanut oil, lactose and some dyes, are known allergens. But if most active ingredients are usually tested to see if they are toxic – and if they are found to have a major effect on most of the population – these toxicology tests may miss certain side effects in some people, according to the report

The study found that 93 percent of pills at least one of the 38 allergens and that almost all of them were constitutive for people with certain food intolerances, such as gluten or sugar.

Still , not all experts are convinced that active ingredients are particularly problematic.

Dr. John Kelso, an allergist and immunologist at Scripps Health in San Diego, California who wasn't involved in the study, is a cause for concern.

"Such reactions are quite rare," he said. "The cases of the food protein [present] in the medication would not be sufficient to trigger an allergic reaction."

For example, the amount of egg protein present in flu shots is not enough to trigger reactions. Even in people with severe eggs allergic to eggs, Kelso customs Live Science. Indeed, the American Academy of Pediatrics revised recommendations for fluids containing eggs, saying that it is no longer necessary to ask people if they are allergic to eggs before giving them the flu vaccine, because the risk is so minimal, he said. ] Kelso said, [forthemajorityofpatientswithfoodallergythereisreasontoavoidmedicationswith[inactive ingredients] derived from the foods to which they are allergic, "Kelso said.

He did note, however, one inactive ingredient in that may cause problems for people with allergies: gelatin. That's because some medications and vaccines are either administered intravenously or injected to contain larger amounts of gelatin, and can trigger allergy reactions.

Originally published on Live Science Originally published on Live Science


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