Thomas Tuchel makes three changes from the side that beat Atletico Madrid in the Champions League: Ben Chilwell, N’Golo Kante and Hakim Ziyech come in for Marcos Alonso, Jorginho and Timo Werner.
Manchester United did not play their best XI against Real Sociedad when they were actually through, but there are two changes from the 3-1 win over Newcastle in their last league game: Scott McTominay, fit again, and Mason Greenwood coming in for Nemanja Matic and Anthony Martial. That means Marcus Rashford is playing in front.
Deputies: Arrizabalaga, Alonso, Zouma, James, Emerson, Jorginho, Pulisic, Havertz, Werner.
Manchester United (4-2-3-1) de Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Greenwood, Fernandes, James; Rashford.
Deputies: Henderson, Bailly, Telles, Williams, Tuanzebe, Matic, van de Beek, Martial, Diallo.
Judging Stuart Attwell.