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Changing the intestinal microbiom may be a potential treatment option for PCOS



Symptoms of polycystic ovarian syndrome (PCOS) improved with exposure to healthy bacteria in the gut, according to a study in a mouse model of the endocrine disorder of this common woman. The study results will be presented Monday at. ENDO 2019, Endocrine Society's Annual Meeting in New Orleans, LA.

This study is based on recent studies by the same investigators showing that the human intestinal microbiome or the intestinal bacterial composition is less diverse in women with PCOS.

"Our new findings suggest that alteration of the intestinal microbial via prebiotic or probiotic therapies may be a potential treatment option for PCOS," said study senior researcher, Varykina Thackray, Ph.D., with the University of California San Diego School of Medicine in La Jolla, California.

PCOS affects about 1

0 percent of women of childbearing age and the exact causes are unknown, according to the Hormon Health Network. It has no cure, but symptoms are treated with medication and changes in diet and exercise. Signs of the disorder include ovarian cystic follicles, higher levels of testosterone, excess body hair, irregular or no menstrual periods, and sometimes weight gain and insulin resistance. Possible long-term health implications include infertility, abortion, pregnancy complications, type 2 diabetes, hypertension and depression.

Thackray and her research team induced PCOS in female mice that passed through puberty by giving them letrozole, an aromatase inhibitor. By blocking the conversion of testosterone to estrogen, this drug results in elevated testosterone levels, and in mice, other characteristics of PCOS also result. Another control group of mice received placebo treatment in this study, which received funding from the National Institute for Child Health and Human Development.

For five weeks, the researchers kept two mice in the cage in three different home arrangements: PCOS mice together, placebo-treated mice together, and mice from both treatment groups together. Co-housing results in exposure to each other's intestinal microbiome, Thackray explained. PCOS mice living with placebo-treated mice had significantly improved testosterone levels, normalized cycles, and ovulation compared to PCOS mice embedded with each other, the investigators reported. In addition, PCOS mice embedded with placebo mice had reduced weight, lower blood sugar and lower insulin levels and less insulin resistance (a major risk factor for type 2 diabetes).

It is important that Thackray said these improvements in PCOS functions were linked to changes in the intestinal microbiome. "Further research is needed to understand how specific intestinal bacteria contribute to PCOS and whether the gut microbiome offers possible pathways to treating the condition," Thackray said.

Source:

https://www.endocrine.org/news -Room / 2019 / endo-2019 — improved pCOS symptoms-correlate-with-gut bacterial composition [19659011] // [19659012]
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